THE DIVERSE SEARCH FOR SYNTHETIC, SEMISYNTHETIC AND NATURAL PRODUCT ANTIBIOTICS FROM THE 1940S AND UP TO 1960 EXEMPLIFIED BY A SMALL PHARMACEUTICAL PLAYER

The 1940s and 1950s witnessed a diverse search for not just natural product antibiotics but also for synthetic and semisynthetic compounds.This review revisits this epoch, using the research by a Danish pharmaceutical company, LEO Pharma, as an example.LEO adopted a strategy searching for synthetic antibiotics toward specific bacterial pathogens, i

Abstract A critical step in the metastatic cascade is the survival of circulating tumor cells (CTCs) within the bloodstream.Although interactions between CTCs and various hematopoietic cells have been described, the role of Facial Cleansing Kits red blood cells (RBCs) remains underexplored.This study investigated the interactions between tumor cell

We analyze how network effects affect competition in the nascent copyright market.We do so by examining early dynamics of exchange rates among different cryptocurrencies.While Bitcoin essentially dominates this Gravy Stock market, our data suggest no evidence of a winner-take-all effect early in the market.Indeed, for a relatively long period, a fe

Laser absorption spectroscopy (LAS) has been used over the last several decades for the measurement of trace gasses in the atmosphere.For over a decade, LAS measurements from multiple sources and tens of retroreflectors have been combined with sparse-sample tomography methods to estimate the 2-D acquerello distribution of trace gas concentrations a